TPSA Calculator
Enter a SMILES string or compound name to retrieve topological polar surface area (TPSA), a common medicinal chemistry property for permeability and oral bioavailability screening.
Enter a compound to calculate.
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What TPSA Tells You
TPSA estimates the polar surface contributed by hetero atoms and attached hydrogens. In Veber-style oral bioavailability guidelines, TPSA at or below about 140 A^2 is often considered favorable, although context matters.