Lipinski Rule Calculator

Enter a SMILES string or compound name to check the four classic Lipinski Rule of Five properties: molecular weight, LogP, hydrogen-bond donors, and hydrogen-bond acceptors.

What Lipinski Rule of Five Means

Lipinski's Rule of Five is a quick oral drug-likeness guideline. A compound is commonly considered more rule-of-five-like when molecular weight is at or below 500, LogP is at or below 5, hydrogen-bond donors are at or below 5, and hydrogen-bond acceptors are at or below 10.

• Rules are screening guidelines, not clinical or biological guarantees.
• Many useful drugs and natural products intentionally violate one or more rules.
• Use the druglikeness calculator for a broader Lipinski plus Veber-style view.