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Common ring systems in drugs template
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Piperidine, pyridine, piperazine, pyrrolidine, imidazole, thiazole, indole, morpholine, quinazoline and tetrazole — the heterocycles that appear again and again in approved drugs, each labelled with an example drug.
What the template shows
- Ten of the ring systems that recur most in approved small-molecule drugs, each with an example
- Ten recurring heterocycles
- A handful of N-heterocycles make up most ring systems in approved drugs (Vitaku, Taylor, 2014); piperidine, pyridine and piperazine lead the list.
- Saturated N-rings (piperidine, piperazine, pyrrolidine, morpholine) add solubility, basicity and 3-D shape; aromatic azines and azoles add H-bond acceptors and tune properties.
- Tetrazole is a carboxylic-acid bioisostere; imidazole and thiazole appear in many binding motifs and natural-product-derived drugs.
- Knowing the common rings helps with scaffold-hopping and with reading new structures quickly.
- Vitaku, Smith & Njardarson, J. Med. Chem. 2014, 57, 10257; Taylor et al. 2014 · every part of this sheet is editable
Drawn with 63 atoms, 2 shapes – every one editable in MolDraw.
Sources
How to use this template
- Press Edit in MolDraw. The template opens on the canvas of the free MolDraw editor.
- Change anything: move structures, edit atoms and labels, recolour highlights or delete what you do not need.
- Add your own structures, arrows and text next to it, or combine several templates on one page.
- Export the drawing as PNG, SVG or PDF for slides, worksheets, theses and papers.
Frequently asked questions
Is the Common ring systems in drugs template free?
You can preview the Common ring systems in drugs template here and open and edit it in MolDraw for free. Downloading or exporting it is part of MolDraw Pro, together with the other premium templates.
Can I edit the Common ring systems in drugs template?
Yes. It opens as an ordinary MolDraw drawing, so every structure, arrow, label and colour can be changed, and you can add your own content around it.
Is the chemistry checked?
Every structure is checked with RDKit and every curly arrow passes MolDraw’s electron-flow audit. The sources used are listed on this page.
Are the IC₅₀ values in the SAR table real?
No. They are illustrative example values so the table can be filled in with your own data; the structures and R-group positions are checked with RDKit.