Reaction Scheme
arene + acyl chloride -> aryl ketoneAlCl3 or another Lewis acid generates the acylium electrophile.
Primary reaction SMILES: c1ccccc1.CC(=O)Cl>>CC(=O)c1ccccc1
Organic reaction
Friedel-Crafts Acylation
Friedel-Crafts acylation installs an acyl group onto an aromatic ring through electrophilic aromatic substitution, commonly using an acyl chloride and Lewis acid.
Two Common Examples
Benzene + acetyl chloride
Forms acetophenone under AlCl3 conditions.
Anisole acylation
Electron-rich anisole gives mostly para-acylated product.
MolDraw Use
Draw substituent effects, acyl chloride partners, and product regiochemistry in MolDraw.