Substrate scope grid template

A general Suzuki scheme over a 4 × 2 grid of biaryl products 3a–3h, each with a bold number and an example yield, with footnotes for changed conditions.

What the template shows

• General scheme on top, then every product in the same orientation with its number and yield
• Scope of the aryl bromide (example data)
• Table 2. Scope of the Aryl Bromideᵃ
• ᵃ Conditions: 1 (0.50 mmol), 2 (0.75 mmol), Pd(dppf)Cl₂ (2 mol%), Cs₂CO₃ (2.0 equiv), dioxane/H₂O (4:1), 80 °C, 12 h; isolated yields. ᵇ 24 h.
• Example data for layout only, not measured results: replace with your own.
• Draw every product in the same orientation, with the part that changes in the same place.
• Bold number and isolated yield under each structure; footnote any change of conditions.
• Group substrates (electron-rich, -poor, heteroaryl) and include the failures: they are useful data.
• Give the scale and conditions once, above the grid, in the general scheme.
• Yields are example data · every part of this figure is editable

Drawn with 128 atoms, 1 arrow, 4 shapes – every one editable in MolDraw.

Sources

• Coghill & Garson, The ACS Style Guide, 3rd ed., ACS/OUP 2006 Textbook
• Miyaura & Suzuki, Chem. Rev. 1995, 95, 2457 Review