SAR table template

A 4-anilinoquinazoline core with R¹ and R² marked and a three-rule table of compounds 5a–5g (R¹, R², IC₅₀ in nM, potency shading), with example data clearly labelled.

What the template shows

• One core scaffold, the positions varied and a journal-style activity table
• Core scaffold and general synthesis
• 4-Anilinoquinazoline (EGFR-inhibitor class): R¹ on C-6, R² on the aniline.
• Activity table (example data)
• Table 1. Effect of R¹ and R² on Inhibition (Example Data)
• OCH₂CH₂OMe
• ᵃ Enzyme assay, mean of n = 3 (state the assay and errors here). Shading: green < 200 nM, yellow < 1 µM, red ≥ 1 µM.
• Example data for layout only, not measured results: replace with your own.
• Draw the common core once, with R¹, R² … at the positions varied, and keep the same orientation as in the text.
• Give units in the column head (IC₅₀, nM) and the assay in a footnote; report errors (± SD, n) or pIC₅₀.
• Order rows so one change at a time can be read down the table (matched pairs).
• Shading by potency helps the eye; say what the colours mean in a footnote.
• Values are invented for the layout · every part of this figure is editable

Drawn with 39 atoms, 1 arrow, 13 shapes – every one editable in MolDraw.

Sources

• Coghill & Garson, The ACS Style Guide, 3rd ed., ACS/OUP 2006 Textbook
• Wermuth et al., The Practice of Medicinal Chemistry, 4th ed., Academic Press 2015 Textbook