---
title: "Kinase hinge-binding motifs Template | MolDraw"
url: https://www.moldraw.com/templates/pharma-kinase-hinge-binders/
description: "Kinase hinge-binding motifs template: Four approved kinase inhibitors with their hinge-binding heterocycle highlighted — imatinib (aminopyrimidine)…"
lang: en
publisher: Scidart Academy
generated: 2026-11-13
---
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# Kinase hinge-binding motifs template

![Kinase hinge-binding motifs template: Four approved kinase inhibitors with their hinge-binding heterocycle highlighted — imatinib (aminopyrimidine), gefitinib and erlotinib (quinazoline) and dasatinib (aminothiazole) — the group that makes the conserved H-bonds to the kinase hinge.](https://www.moldraw.com/templates/pharma-kinase-hinge-binders.webp)

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Four approved kinase inhibitors with their hinge-binding heterocycle highlighted — imatinib (aminopyrimidine), gefitinib and erlotinib (quinazoline) and dasatinib (aminothiazole) — the group that makes the conserved H-bonds to the kinase hinge.

## What the template shows

- The heterocycle that makes the conserved hydrogen bonds to the ATP-site hinge
- Four inhibitors, hinge binder circled
- hinge-binding heterocycle
- aminopyrimidine · BCR-ABL
- quinazoline · EGFR
- aminothiazole · BCR-ABL / SRC
- ATP-competitive kinase inhibitors bind in the ATP pocket and make one to three hydrogen bonds to the backbone of the “hinge” that links the two kinase lobes — just as the adenine of ATP does.
- A flat, H-bond-accepting (and often donating) heterocycle carries these contacts: aminopyrimidine, quinazoline N1/N3, aminothiazole, pyrrolo/pyrazolo-pyrimidine and the like.
- The rest of the molecule reaches into selectivity pockets (hydrophobic back pocket, the gatekeeper, the DFG motif), which sets potency and selectivity.
- Recognising the hinge binder is a fast way to read a kinase inhibitor and to scaffold-hop between series.
- Roskoski, Pharmacol. Res. 2016, 103, 26 · every part of this sheet is editable

Drawn with 130 atoms, 7 shapes – every one editable in MolDraw.

## Sources

- [Roskoski, Pharmacol. Res. 2016, 103, 26](https://doi.org/10.1016/j.phrs.2015.10.021) Review

## How to use this template

1. Press **Edit in MolDraw**. The template opens on the canvas of the free MolDraw editor.
2. Change anything: move structures, edit atoms and labels, recolour highlights or delete what you do not need.
3. Add your own structures, arrows and text next to it, or combine several templates on one page.
4. Export the drawing as PNG, SVG or PDF for slides, worksheets, theses and papers.

## Frequently asked questions

### Is the Kinase hinge-binding motifs template free?

You can preview the Kinase hinge-binding motifs template here and open and edit it in MolDraw for free. Downloading or exporting it is part of MolDraw Pro, together with the other premium templates.

### Can I edit the Kinase hinge-binding motifs template?

Yes. It opens as an ordinary MolDraw drawing, so every structure, arrow, label and colour can be changed, and you can add your own content around it.

### Is the chemistry checked?

Every structure is checked with RDKit and every curly arrow passes MolDraw’s electron-flow audit. The sources used are listed on this page.

### Are the IC₅₀ values in the SAR table real?

No. They are illustrative example values so the table can be filled in with your own data; the structures and R-group positions are checked with RDKit.

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