--- title: "Mizoroki–Heck reaction Template | MolDraw" url: https://www.moldraw.com/templates/cycle-mizoroki-heck/ description: "Mizoroki–Heck reaction template: Catalytic cycle of the Heck reaction with methyl acrylate: oxidative addition of Ar–X, syn migratory insertion of the…" lang: en publisher: Scidart Academy generated: 2026-10-28 --- [MolDraw](https://www.moldraw.com/) › [Templates](https://www.moldraw.com/templates/) › [Catalytic cycles](https://www.moldraw.com/templates/catalytic-cycles/) › Mizoroki–Heck reaction [Catalytic cycles](https://www.moldraw.com/templates/catalytic-cycles/)Free # Mizoroki–Heck reaction template ![Mizoroki–Heck reaction template: Catalytic cycle of the Heck reaction with methyl acrylate: oxidative addition of Ar–X, syn migratory insertion of the alkene, syn β-hydride elimination giving the (E)-cinnamate, and base-assisted loss of HX from H–Pd–X; key step: migratory insertion with curly arrows.](https://www.moldraw.com/templates/download/cycle-mizoroki-heck.svg) [Edit in MolDraw](https://www.moldraw.com/)[Download SVG](https://www.moldraw.com/templates/download/cycle-mizoroki-heck.svg) Free template. Download it, or open it in MolDraw to change it first. Catalytic cycle of the Heck reaction with methyl acrylate: oxidative addition of Ar–X, syn migratory insertion of the alkene, syn β-hydride elimination giving the (E)-cinnamate, and base-assisted loss of HX from H–Pd–X; key step: migratory insertion with curly arrows. ## What the template shows - An aryl halide and an alkene give a substituted alkene; a base turns H–Pd–X back into Pd(0) - Overall: Ar–X + CH₂=CH–CO₂Me → (E)-Ar–CH=CH–CO₂Me (cat. Pd(0)L₂, Et₃N) - L₂XPd–alkyl - no organometallic reagent - No organometallic partner: the alkene C–H is replaced, so only a base (Et₃N, K₂CO₃, NaOAc) is consumed. - Insertion is syn and regioselective: the aryl group goes to the less substituted alkene carbon. - β-Hydride elimination is also syn and gives mainly the E (trans) alkene. - The base removes HX from H–Pd(II)–X, closing the cycle (Nobel Prize 2010 with Negishi and Suzuki). - Key step: syn migratory insertion (carbopalladation) - The Pd–Ar bond electrons carry the aryl group to the CH₂ end of the alkene while the C=C π electrons form the new Pd–C bond: a four-centre syn addition that puts Pd on the carbon bearing CO₂Me, ready for β-hydride elimination. - methyl acrylate - L = phosphine (e.g. PPh₃); ligands are named in the captions, not drawn · every part of this figure is editable Drawn with 34 atoms, 7 arrows, 83 shapes – every one editable in MolDraw. ## Sources - [Beletskaya & Cheprakov, Chem. Rev. 2000, 100, 3009](https://doi.org/10.1021/cr9903048) Review - [Hartwig, Organotransition Metal Chemistry: From Bonding to Catalysis, University Science Books 2010](https://openlibrary.org/isbn/9781891389535) Textbook ## How to use this template 1. Press **Edit in MolDraw**. The template opens on the canvas of the free MolDraw editor. 2. Change anything: move structures, edit atoms and labels, recolour highlights or delete what you do not need. 3. Add your own structures, arrows and text next to it, or combine several templates on one page. 4. Export the drawing as PNG, SVG or PDF for slides, worksheets, theses and papers. ## Frequently asked questions ### Is the Mizoroki–Heck reaction template free? Yes. The Mizoroki–Heck reaction template is one of the free MolDraw templates: open it in the editor or download it from this page as SVG or PNG and use it in your slides, worksheets and notes. ### Can I edit the Mizoroki–Heck reaction template? Yes. It opens as an ordinary MolDraw drawing, so every structure, arrow, label and colour can be changed, and you can add your own content around it. ### Is the chemistry checked? Every structure is checked with RDKit and every curly arrow passes MolDraw’s electron-flow audit. The sources used are listed on this page. ### What does a catalytic cycle template show? The active catalyst, each intermediate around the cycle, the substrates that enter and the products that leave, with each elementary step named on its arrow. ## More catalytic cycles templates [**Suzuki–Miyaura coupling**Free · Catalytic cycles](https://www.moldraw.com/templates/cycle-suzuki-miyaura/)[**Olefin metathesis (Chauvin mechanism)**Free · Catalytic cycles](https://www.moldraw.com/templates/cycle-olefin-metathesis/)[**Buchwald–Hartwig amination**Premium · Catalytic cycles](https://www.moldraw.com/templates/cycle-buchwald-hartwig/)[**Sonogashira coupling**Premium · Catalytic cycles](https://www.moldraw.com/templates/cycle-sonogashira/)[**Negishi coupling**Premium · Catalytic cycles](https://www.moldraw.com/templates/cycle-negishi/)[**Stille coupling**Premium · Catalytic cycles](https://www.moldraw.com/templates/cycle-stille/)[**Wilkinson's catalyst: alkene hydrogenation**Premium · Catalytic cycles](https://www.moldraw.com/templates/cycle-wilkinson-hydrogenation/)[**Wacker oxidation**Premium · Catalytic cycles](https://www.moldraw.com/templates/cycle-wacker-oxidation/) ## Related pages [**All Catalytic cycles templates**10 templates](https://www.moldraw.com/templates/catalytic-cycles/)[**All chemistry templates**370 templates in 29 categories](https://www.moldraw.com/templates/) MolDraw Pro Download all 370 templates - Export the 291 premium templates as PNG, SVG or PDF - AI chemistry assistant - Structure scanning from images - Cloud save and teaching slides [See Pro plans](https://www.moldraw.com/pricing) Free templates stay free. 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